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DNA REPLICATION

DNA REPLICATION

DNA REPLICATION

DNA STRUCTURE

DNA REPLICATION

FIGURE 13.2 page 354

FIGURE 13.4, page 355

REPLICATION ORIGINS

FIGURE 13.7, page 357

FIGURE 13.8, page 359

REPLICONS

FIGURE 13.9, page 359

YEAST REPLICON- ARS

FIGURE 13.10, page 360

DNA
REPLICATION

CHAPTER 12/13

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DNA REPLICATION

CHAPTER 12/13

DNA REPLICATION

FUNDAMENTAL TO REPRODUCTION IS
THE ABILITY TO PASS A COMPLETE COPY OF THE GENOME TO THE NEXT GENERATION

THE PRODUCTION COPIES OF THE
GENETIC MATERIAL IS BY THE REPLICATION OF THE DNA

DNA REPLICATION

THE NATURE OF DNA - THE TWO
STRANDS OF NUCLEOTIDES- SUGGESTS THE METHOD FOR REPLICATING

? HOW DOES THIS STRUCTURE
RELATE TO THE ABILITY TO REPLICATE?

DNA STRUCTURE

DNA REPLICATION

WHEN DNA IS REPLICATED, ITS
DOUBLE STRANDED NATURE REQUIRES THAT REPLICATION STARTS AT A SPECIFIC SITE
(REPLICATION ORIGIN)

THE DNA IS THEN UN-WOUND AND
REPLICATED EITHER 1 DIRECTION OR BOTH DIRECTIONS

FIGURE 13.2 page 354

FIGURE 13.4, page 355

REPLICATION ORIGINS

THE GENERAL FEATURE OF THESE
SEQUENCES OF DNA:

AT RICH

BACTERIA GENERALLY HAVE 1

EUKARYOTIC CELLS HAVE MULTIPLE

IN BACTERIA, DELETION STUDIES
HAVE SHOWN THAT A 245 bp REGION CRITICAL FOR REPLICATION

FIGURE 13.7, page 357

FIGURE 13.8, page 359

REPLICONS

EUKARYOTIC REPLICONS ARE
SMALLER AND SLOWER THAN PROKARYOTIC ONES:

BACTERIA  4200 kb 50,000 bp/min

YEAST     40 kb 3,600

MOUSE   150 kb 2.200

TOAD   200 kb
500

FIGURE 13.9, page 359

YEAST REPLICON- ARS

IN YEAST, THE ORIGIN HAS BEEN
ISOLATED AND IDENTIFIED

CALLED THE ARS (AUTONOMOUSLY
REPLICATING SEQUENCE)

ARS SEQUENCES HAVE BEEN STUDIED
USING POINT MUTATIONS (SINGLE CHANGES IN A BASE) TO EXAMINE IMPORTANT REGIONS
FOR FUNCTION

FIGURE 13.10, page 360

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DNA
REPLICATION

FUNDAMENTAL
TO REPRODUCTION IS

THE ABILITY TO
PASS A COMPLETE

COPY OF THE
GENOME TO THE NEXT

GENERATION

THE
PRODUCTION COPIES OF THE

GENETIC MATERIAL
IS BY THE

REPLICATION OF
THE DNA