ZACHARY F. WALLS
ZACHARY F. WALLS
SUB-CELLULAR PHARMACEUTICS LABORATORY
subcellular drug delivery, molecular imaging, predictive algorithm design
Associate Professor
Pharmaceutical Sciences
Gatton College of Pharmacy
Ph.D., University of California Los Angeles, 2008, Molecular & Medical Pharmacology
B.S., Tulane University,
2001, Mathematics, Cell/Molecular Biology
East Tennessee State University
Johnson City, TN 37614
423-439-6236
Office: Pharmacy 319
Lab: Stanton-Gerber A125
Academic Distinctions
AACP New Investigator Award, 2013
Research Training in the Pharmacological Sciences Fellow, 2002-2005
Bioinformatics Integrated Graduate Education and Research Trainee, 2002
Mathematical Biology REU Fellow, 2000
Appointments
Postdoctoral Researcher, University of Michigan, 2008-2011
Research Foci
1) Building tools for the delivery of drugs (small and macro) into specific organelles of mammalian cells: In order for drugs to interact with targets inside the cell, they must overcome a number of barriers. Various microorganisms have evolved mechanisms for overcoming these barriers in order to deliver their own genetic material and replicate within host cells. Our goal is to adapt these mechanisms and combine them into a single delivery vehicle that can successfully deliver macromolecular therapeutics to diseased cells.
2) Designing algorithms that can predict functional responses based on drug profiles: An individual’s drug regimen is reflective of overall health status and can be indicative of various multifactorial clinical outcomes. Our goal is to develop and validate computational algorithms that can predict clinical outcomes based solely on medication profiles.
Publications
Hall CD, Karpen S, Odle BL, Panus PC, Walls ZF. “Development and Evaluation of the Medication-based Index of Physical function (MedIP)” Age and Aging. 2017.
Anson E, Thompson E, Odle BL, Jeka J, Walls ZF, Panus PC. “Influences of Age, Obesity, and Adverse Drug Effects on Balance and Mobility Testing Score in Ambulatory Older Adults.” J Geriatr Phys Ther. 2017.
Walls ZF, Gong H, Wilson RJ. “Liposomal Coencapsulation of Doxorubicin with Listeriolysin O Increases Potency via Subcellular Targeting.” Mol Pharm. 13(3):1185-90, 2016.
Walls ZF, Bossaer JB, Cluck D. “Using Scientific Inquiry to Increase Knowledge of Vaccine Theory and Infectious Diseases.” Educ Health (Abingdon). 29(2):95-106, 2016.
Walls ZF, Gupta SV, Amidon GL, Lee KD. “Synthesis and Characterization of Valyloxy Methoxy Luciferin for the Detection of Valacyclovirase and Peptide Transporter.” Bioorg Med Chem Lett. 24(20):4781-3, 2014.
Loening AM, Walls ZF. “Engineering Luciferase for Assays and Imaging.” Engineering in Translational Medicine. Ed. Cai W. Springer, 2014.
Walls ZF, Goodell S, Andrews CD, Mathis J, Lee KD. “Mutant of listeriolysin O for enhanced liposomal drug delivery of macromolecules.” J Biotechnol. 164(4):500-502, 2013.
Sun J, Dahan A, Walls ZF, Lai L, Lee KD, Amidon GL. “Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect.” Mol Pharm. 7(6):2362-8, 2010.
Walls ZF, Puttaraju M, Temple GF, Gambhir SS. “A Generalizable Strategy for Imaging pre-mRNA Levels in Living Subjects Using Spliceosome-Mediated RNA Trans-splicing.” J Nucl Med. 49(7):1146-1154, 2008.
Walls ZF, Gambhir SS. “BRET-based method for detection of specific RNA species.” Bioconjug Chem. 19(1):178-84, 2008.
Gambhir SS, Deroose C, Walls Z. “Cell Biology Fundamentals.” Nuclear Medicine in Clinical Diagnosis and Treatment, 3rd Ed. Eds. Ell PJ, Gambhir SS. New York, NY: Churchill Livingstone, 2004. 1687-1713.
Bhaumik S, Walls Z, Puttaraju M, Mitchel LG, Gambhir SS. “Molecular imaging of gene expression in living subjects by spliceosome-mediated RNA trans-splicing.” PNAS. 101 (23):8693-8, 2004.
Chauvet E, Paullet JE, Previte JP, Walls Z. “A Lotka-Volterra Three-species Food Chain” Mathematics Magazine. 75(4):243-255, 2002.
Former Lab Members:
Irene Abia, PhD
Katie Barron, PharmD
Chris Blackburn, PharmD
Wesley Brillhart
Josh Brown, PharmD
Jennifer Carmical, PharmD
Laura Cyphers, PharmD
Jun Dai
Henry Gong
Elle Harrison, BS
Brent Henderson, PharmD
Moses Holleyman, PharmD
Tyler Jones, PharmD
Stephen Lance, PharmD
Monica Masters
Alex Mink, PharmD
Ryan Pritchard, PharmD
Matt Schwengels, PharmD
Dana Suich, PharmD
Benjamin Sypniewski, PharmD
Teddy Taylor
Robert Vincent, PharmD
Wes Waters, PharmD
Stephen Widing, PharmD
Rebecca Wilson