PUBLICATIONS

Selected Publications

  1. Ospanov, M.; Sulochana, S.P.; Paris, J.J.; Rimoldi, J.M.; Ashpole, N.; Walker, L.; Ross, S.A.; Shilabin, A.G.; Ibrahim, M.A. Identification of an Orally Bioavailable, Brain-Penetrant Compound with Selectivity for the Cannabinoid Type 2 Receptor. Molecules 2022, 27, 509.
  2. Mingle, D.; Ospanov M.; Radwan, M. O.; Ashpole, N.; Otsuka, M.; Ross, S. A.; Walker, L.; Shilabin, A. G.; Ibrahim, M. A. First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-PBD Analogs As Selective CB2  Modulators Targeting Neurodegenerative Disorders. Med. Chem. Res.  2021, 98-108.
  3. Ward, A. L.; Manikindi, P.; Borisova, R.; Shilabin A. G.; Lampson, B. C. A small inhibitory compound produced by a soil isolate of Rhodococcus has strong activity against the veterinary pathogen R. equi. PLOS ONE. 2018, 13(12):e0209275.
  4. Annor-Gyamfi, J. K.; Jarrett, J. M.; Osazee, J. O.; Bialonska, D.; Whitted, C.; Palau, V. E.; Shilabin, A. G. Synthesis and Biological Activity of Fused Tetracyclic Pyrrolo[2,1-C] [1,4]Benzodiazepines. Heliyon 2018, 4, 1-19.
  5. Ibrahim, M. A.; El-Alf, A. T.; Ezell K.; Radwan, M. O.; Shilabin, A. G.; Kochanowska, A. J.; Abd-Alla, H. I.; Otsuka, M.; Hamann, M. T. Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space. Mar. Drugs 2017, 15(8), 248.
  6. Adediran, S. A.; Wang, P.-F.; Shilabin, A. G.; Baron, C. A.; McLeish M. J.; Pratt, R. F. Specifity and Mechanism of Mandelamide Hydrolase Catalysis. Arch. Biochem. Biophys. 2017, 618, 23-31.
  7. Osazee, J. O.; Annor-Gymafi, J. K.; Slebodnick, C.; Shilabin, A. G., Structure-Based Discovery and Synthesis of Pyrrolo[2,1-c][1,4]-benzodiazepine Derivatives as Non-β-lactam Serine β-lactamase Inhibitors. Int. J. Drug Dev. & Res. 2016, 8, 24-33.
  8. Kasanah, N.; Lucas Farr, L.; Gholipour Shilabin, A.; Wedge, D. E.; Hamann, M. T. Metabolism and Resistance of Fusarium spp. to the Manzamine Alkaloids via a Putative Retro Pictet-Spengler Reaction and Utility of the Rational Design of Antimalarial and Antifungal Agents. Mar. Biotechnol. 2014, 16, 412-422.
  9. Ahern J. C.; Shilabin A. G.; Henline, K. M.; Pike, R. D.; Patterson, H. H. Photophysical properties of {[Ag(CN)2]-}2 complexes trapped in a supramolecular electron-acceptor organic framework. Dalton Trans. 2014, 43, 12044-12049.
  10. Shilabin, A. G.; Dzhekieva, L.; Misra, P; Jayaram B.; Pratt, R. F. 4-Quinolones as Noncovalent Inhibitors of High Molecular Mass Penicillin-Binding Proteins. ACS Med. Chem. Lett. 2012, 3, 592-595.
  11. Chen, L.: Lei, Y.; Shilabin, A. G., Baran, G. R.; Sieburth, S. M. β-Peptide Coatings by Surface-Initiated Polymerization. Chem. Commun. 2012, 48, 9604-9606.
  12. Shilabin, A. G.; Hamann, M. T. Synthesis and Evaluation of Kahalalide F Analogs with Improved Antitumoral and Antimicrobial Activities. Bioorg. Med. Chem. 2011, 19, 6628-6632.
  13. Gao, J.; Caballero-George, C., Wang, B.; Rao, K. V.; Shilabin, A. G.;Hamann, M. T. 5-OHKF and NorKA, Depsipeptides from a Hawaiian Collection of Bryopsis pennata: Binding Properties for NorKA to the Human Neuropeptide Y Y1 Receptor. J. Nat. Prod. 2009, 79, 2172-2176.
  14. Shilabin, A. G.; Kasanah, N.; Tekwani, B. L.; Hamann, M. T. Kinetic Studies and Bioactivity of Potential Manzamine Prodrugs. J. Nat. Prod. 2008, 71, 1218-1221.
  15. Ibrahim, M. A.; Shilabin, A. G.;Prasanna, S.; Jacob, M.; Khan, S. I.; Doerksen, R. J.; Hamann, M. T. 2-N-Methyl Modifications and SAR Studies of Manzamine A. Bioorg. Med. Chem. 2008, 16 , 6702-6706.
  16. Schmidt, A.; Lindner A. S.; Shilabin, A. G.; Nieger, M. New Derivatives and Ring Systems of Annulated Pyrrolobenzo[1,4]diazepins. Tetrahedron 2008, 64, 2048-2056.
  17. Shilabin, A. G.; Kasanah, N.; Wedge, D. E.; Hamann, M.T. The Lysosome and HER3 (ErbB3) Selective Anticancer Agent Kahalalide F: Semisynthetic Modifications and Structure-Activity Relationship Studies. J. Med. Chem. 2007,50, 4340-4350.
  18. Schmidt,  A.; Shilabin, A. G.;Namyslo, J. C.; Nieger, M.; Hemmen, S. Pyrimidine-annulated Pyrrolobenzodiazepines. A New Ring System Related to Aspergillus Alkaloids. Eur. J. Org. Chem. 2005, 1781-1789.
  19. Schmidt, A.; Shilabin, A. G.; Nieger, M. Syntheses and Tautomerisations of Amino-Substituted and Pyrimidine-Annulated Pyrrolobenzodiazepines. Heterocycles 2005, 65, 625-632.
  20. Schmidt, A.; Shilabin, A. G.Thia-diazabenzo[g]cyclopenta[e]azulene-diones. Syntheses and Properties of a New Ring System. Heterocycles 2004, 63, 2851-2858.
  21. Schmidt, A.; Shilabin, A. G.; Nieger, M. On Benzo[b][1.4]diazepinium-olates, -thiolates and -carboxylates as Anti-Hückel Mesomeric Betaines. Org. Biomol. Chem. 2003, 1, 4342-4350.
  22. Schmidt, A.; Shilabin, A. G.;Nieger, M. Synthesis and X-ray Structure of 2,4-Dimethyl-6,7-benzo[1,5]diazepinium Picrates. Heterocycles 2003, 60, 2645-2651.
  23. Shilabin, A. G.; Entezami, A. A.Electrochemical Behavior of Conducting Polyfuran Derivatives Containing Pyrrole, Thiophene and Ethylenic Spacers. Eur. Poly. J. 2000, 36, 2005-2020.

 Presentations

  1. Departmental Research Seminar, University of Maine, May 2013. Oral presentation. Drug Discovery: Synthesis and SAR Studies of Bioactive Natural Products.
  2. Departmental Chemistry Colloquium, Wesleyan University, February 2011. Oral presentation. E. coli PBP5 DD-Carboxypeptidase: The Search for New Efficient Inhibitors. Biochemistry Seminar, Wesleyan University, January 2010. Oral presentation. Bioactive Marine Natural Products.
  3. Gordon Research Conference-Drug Resistance, University of New England, Biddeford, ME, June 12-17, 2016. Poster presentation. Shilabin, A. G.; Ossazi, J.; Annor-Gyamfi, J. The Search for New Class of Non-ß-lactam Serine ß-Lactamase Inhibitors: Design and Synthesis of Pyrimidinone and Oxadiazolinones. 
  4. Semisynthesis and SAR Studies.247th American Chemical Society National Meeting & Exposition, Division of Medicinal Chemistry, Dallas, TX, March 16-20, 2014. Poster presentation. Shilabin, A. G.; Dzhekieva, L.; Jayaram B.; Pratt, R. F. Fragment-Based Design, Synthesis, and Evaluation of a New Class of Effective Non-β-lactam Inhibitors of High Molecular Mass Penicillin-Binding Proteins. 
  5. 43rd National Organic Chemistry Symposium, the University of Washington, Seattle, WA, June 23-27, 2013. Poster presentation. Brenden P. Derstine, Li Chen, Yong Lei, Abbas G. Shilabin, James D. Delaney, George R. Baran and Scott McN. Sieburth, β-Lactam Composites via Surface-Initiated Polymerization.
  6. 22nd Enzyme Mechanisms Conference, St. Pete Beach, Florida, USA, January 2-6, 2011. Poster presentation. Shilabin, A. G.; Jayaram B. & Pratt, R. F., Design, Synthesis and Evaluation of Quinolone-based Inhibitors of E. coli PBP5.
  7. European Cooperation in Science and  Technology (COST), Proceedings of the COST Strategic Workshop, Principles and Development of Bio-inspired Materials, Vienna, Austria, April 13-15, 2010. Poster presentation. Shilabin, A. G.; Wang, W.; Lei, Y.; Sadeghipour, K.; Baran, G. & Sieburth, S. M., Design of Composites with Nacre-Protein-Analogue Interphases.
  8. 238th American Chemical Society National Meeting, Organic Chemistry Section, Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules Session, Washington, DC, August 16-20, 2009. Poster presentation. Shilabin, A. G.; Baran, G.; Sieburth, S. M. & Wan, Q., Nature-inspired peptidomimicry: Growth of β-peptides on glass surfacess.
  9. 236th American Chemical Society National Meeting, Biologically-Related Molecules Section, Philadelphia, PA, August 17-21, 2008. Poster presentation. Shilabin, A. G.; Kasanah, N. & Hamann, M. T., Kahalalide F: Semisynthetic modifications and antifungal lead-exploration studies.
  10. 236th American Chemical Society National Meeting, Peptides, Proteins and Amino Acids Section, Philadelphia, PA, August 17-21, 2008. Poster presentation. Shilabin, A. G.; Baran, G. & Sieburth, S. M., Biocomposite mimicry: Glass surfaces grafted with poly-b-peptides.
  11. 235th American Chemical Society National Meeting & Exposition, New Orleans, LA, April 6-10, 2008. Poster presentation. Ibrahim M. A.; Shilabin, A. G. & Hamann, M. T., Semisynthetic Modifications and SAR Studies of Manzamine A Analogs.
  12. The Philadelphia Section of the American Chemical Society, Temple University, Philadelphia, PA, January 24, 2008. Poster presentation. Shilabin, A. G.; Baran, G. & Sieburth, S. M., Nature-Inspired Peptidomimetic Polymers: Development of Novel Bioadhesive Poly-β-Peptides Based Synthetic Composites.
  13. Annual meeting of American Society of Pharmacognosy, Portland, ME, July 14-19, 2007. Poster presentation. Kasanah, N.; Clemens, A.; Shilabin, A. G.; Peng, J.; Anderson, M.; Wahyuono, S.; Hill, R.T. & Hamann, M.T., Marine peptides and their activity as anti-infective agents
  14. 223rd American Chemical Society National Meeting & Exposition, Agricultural & Food Chemistry Section, Chicago, IL, March 25-29, 2007. Poster presentation. Kasanah, N.; Shilabin, A. G.; Lucas, L. A.; Wedge, D. E. & Hamann, M. T., Evaluation mechanism of resistance by Fusarium to the manzamine alkaloids.
  15. Annual meeting of American Society of Pharmacognosy, Washington DC, August 4-10, 2006. Poster presentation. Kasanah, N.; Shilabin, A. G.;Lucas, L.A.; Wedge, D. E. & Hamann, M. T.,The evaluation of resistance Fusarium spp to manzamine and its analogs.
  16. Chemiedozententagung, München März 6-9, 2005. Schmidt, A.; Merkel, L.; Shilabin, A. G.;Habeck, T.; Mordhorst, T. and Fleischhauer, H., Nucleophile Carbene und Verwandte aus Naturstoffen.
  17. Chemiedozententagung, Dortmund, April 2004. Schmidt, A.; Mordhorst, T.; Shilabin, A. G. &Habeck, T., (Naturstoff-) Chemie mit heteroaromatischen Oligokationen und mesomeren Betainen. Abstract C-28, 7.3.